WebMar 25, 2024 · RCSB PDB - 6YET: Second EH domain of AtEH1/Pan1 Structure Summary NMR Ensemble 3D View : Structure 1D-3D View Validation Report Ligand Interaction Macromolecule Content Total Structure Weight: 12.38 kDa Atom Count: 858 Modelled Residue Count: 104 Deposited Residue Count: 106 Unique protein chains: 1 Display … WebApr 23, 2024 · Collectively, our structural and functional studies reveal distinct but complementary roles of the EH domains of AtEH/Pan1 in plant CME and connect the internalization of SCAMP5 to the TPLATE complex. AtEH/Pan1 proteins contain two N-terminal Eps15 homology (EH) domains and are subunits of the endocytic TPLATE …
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WebAug 13, 2024 · In Arabidopsis, AtEH/Pan1 proteins play a dual role, where on one hand, they drive actin-mediated autophagy, and on the other hand, they bind auxiliary endocytic adaptors as well as the plasma membrane (Wang et al., 2024; Yperman et al., 2024). WebMay 24, 2024 · The AtEH/Pan1 proteins are the plant homologs of yeast Pan1p, which is known for its role as an activator of ARP2/3-dependent actin dynamics during endocytosis 9 – 11. Pan1p was also recently shown to be part of a phosphorylation-dependent mechanism connecting endocytic vesicles, endosomal compartments, and actin dynamics in budding … gasthof hubertusstube st. johann
Distinct EH domains of the endocytic TPLATE complex confer …
WebAtEH1/Pan1 and AtEH2/Pan1 are essential for plant life. In AtEH1/Pan1 heterozygous mutants, shrivelled and normal looking pollen grains are observed in a ratio of 1:1 (Fig. 2a), similar to... WebUtilizing advanced time-lapse imaging and kymograph analysis, the authors show that the TPLATE, AtEH1/Pan1, and AtEH2/Pan1 TPC subunits are recruited to the PM simultaneously, at both 25°C and 12°C ( Fig. 1 ). WebIn particular, two TPC members, AtEH1/Pan1 and AtEH2/Pan1 play an important role in this pathway (Figure 8) and several components of the endocytic machinery are associated with this pathway, either as machinery or as cargo. Ongoing research focusses on unravelling in detail how this pathway is initiated, as well as how it is connected to the ... david schink obituary