Stub1 chip

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August undefined, 2024

WebDescription: Homo sapiens STIP1 homology and U-box containing protein 1 (STUB1), transcript variant 2, mRNA. (from RefSeq NM_001293197) RefSeq Summary (NM_001293197): This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and …

STUB1/CHIP promotes ubiquitination and degradation of HIV-1 Vif …

WebNov 16, 2024 · STUB1 disassociates AR/AR-V7 from HSP70, leading to AR/AR-V7 ubiquitination and degradation. ... The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat. Cell ... CHIP enhances HSP70 induction during acute stress and also mediates its turnover during the stress recovery process. Hence CHIP appears to maintain protein homeostasis by controlling chaperone levels during stress and recovery. Mutations in STUB1 cause spinocerebellarataxiatype 16. Interactions. STUB1 … See more STUB1 (STIP1 homology and U-Box containing protein 1) is a human gene that codes for the protein CHIP (C terminus of HSC70-Interacting Protein). See more The CHIP protein encoded by this gene binds to and inhibits the ATPase activity of the chaperone proteins HSC70 and HSP70 and blocks the … See more • Patterson C (Jan 2002). "A new gun in town: the U box is a ubiquitin ligase domain". Science's STKE. 2002 (116): pe4. doi See more STUB1 has been shown to interact with: • C-Raf, • DNAJB1, • HSPA1A, • HSPA4, See more • STUB1 human gene location in the UCSC Genome Browser. • STUB1 human gene details in the UCSC Genome Browser. See more personal insolvency agreement australia

Recombinant AP Anti-STUB1 / CHIP antibody [EPR4447] …

WebThe carboxy terminus of Hsc70-interacting protein (CHIP, STUB1) is a co-chaperone protein and functional E3 ubiquitin ligase that links the polypeptide binding activity of Hsp70 to … WebThis product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility. - Improved sensitivity and specificity. - Long-term security of supply. - Animal-free production. For more information see here. Our RabMAb ® technology is a patented hybridoma-based technology ... WebBrowse the : « Home » page. Food Basics, always more for less! personal inland marine insurance companies

CHIP as a therapeutic target for neurological diseases

Anti-STUB1/CHIP antibody (ab2917) Abcam

WebMay 25, 2015 · STUB1/CHIP is a E3 ligase protein that ubiquitylates and tags other proteins for degradation. It is involved in major developmental processes for the downstream expression and/or stabilization of ... WebSynthetic peptide within Human STUB1/CHIP aa 1-100 (N terminal). The exact sequence is proprietary. Positive control HeLa, MCF-7, 293T and ECV-304 cell lysates; Human skeletal muscle tissue. General notes This … standard health collegeWebSep 9, 2024 · Carboxy-terminus of Hsc70-interacting protein (CHIP), also termed STUB1, is a 35 kDa protein with the dual function of co-chaperone and E3 ubiquitin ligase activity 3,4. personal insight of islam

"WebSTUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down’s syndrome patients. " - Stub1 chip

Stub1 chip

WebNov 4, 2024 · Structure of the STUB1 TPR domain in complex with H204, an all-D Helicon Polypeptide WarningYou are using a web browser that we do not support. Our website will not work properly. Please update to a newer version or download a new web browser, such as Chrome or Firefox. Contact us Toggle navigationRCSB PDB Deposit Prepare Data … WebMar 26, 2024 · CHIP/STUB1 Antibody (C-10) is a mouse monoclonal IgG 1 κ, cited in 16 publications, provided at 200 µg/ml raised against amino acids 73-303 mapping at the C-terminus of CHIP of human origin Anti-CHIP/STUB1 Antibody (C-10) is recommended for detection of CHIP of mouse, rat and human origin by WB, IP, IF and ELISA

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WebSTUB1/CHIP was also immunoprecipitated by rabbit anti-STUB1/CHIP antibody (Product # A301-573A), which recognizes a downstream epitope. For blotting immunoprecipitated … WebDescription Rabbit polyclonal to STUB1/CHIP Host species Rabbit Specificity Detects human carboxyl terminus of hsc70-interacting protein (CHIP).Detects a band of approximately 35 kDa representing CHIP from COS-1 cells overexpressing the human gene including a non-specific band at 80kDa .

WebSTUB1 encodes for the protein C-terminus of Hsc70 Interacting Protein (CHIP), an E3 ubiquitin ligase. CHIP is known to regulate proteostasis by recruiting chaperones via a N-terminal… Show more Web2 days ago · The E3 ligases c-Cbl and CHIP are ubiquitination regulators of BCR/ABL. 23 They induce ubiquitin-dependent degradation of mature and immature BCR/ABL, respectively, and efficiently suppress BCR/ABL-dependent leukemic growth. 23 Arsenic sulfide (As 4 S 4) has been reported to upregulate c-Cbl, to enhance the ubiquitination and …

WebApr 8, 2024 · More interestingly, the E3 ubiquitin ligase STIP1 homology and U-box containing protein 1 (STUB1, also known as CHIP and encoded by STUB1) emerged as … WebAug 1, 2024 · STUB1 is a chaperone-associated E3 ubiquitin ligase. Previous study has shown that single-point K30A mutation in the TPR domain abolishes the binding of STUB1 to chaperones (Hsc70 or Hsp90), which results in the attenuated STUB1-substrate interaction as well as the reduced ubiquitination of substrates ( Yonezawa et al., 2024 ).

WebSTUB1/CHIP is 303 amino acids (aa) in length with a predicted molecular weight of 34.8 kDa. Human STUB1/CHIP shares 97% aa sequence identity with the mouse ortholog but only 67% sequence identity with the rat …

WebJul 27, 2024 · The STUB1 gene (STIP1 Homology And U-Box Containing Protein 1) encodes the CHIP protein containing tetratricopeptide repeats and a U-box that functions as a ubiquitin ligase/cochaperone, involved ... personal insolvency practitioner shropshireWebSTIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase Synonyms: CHIP, HSPABP2, NY-CO-7, SDCCAG7, UBOX1 Species: Human STUB1 (10273), Mouse Stub1 (56424), Rat Stub1 (287155), Zebrafish... Summary: STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in... Related Products: standard health insuranceWebSTUB1/CHIP Antibody (A301-572A) in WB Detection of human and mouse STUB1/CHIP by western blot (h&m) and immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded), 293T … personal insight and developmentWebSep 24, 2024 · The ubiquitin ligase CHIP (C-terminus of Hsc70-interacting protein) is encoded by STUB1 and promotes ubiquitination of misfolded and damaged proteins. CHIP deficiency has been linked to several diseases, and mutations in the human STUB1 gene are associated with recessive and dominant forms of spinocerebellar ataxias (SCAR16/SCA48). standard health insurance companyWebSTUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down's syndrome patients. personal insight in tagalogWebApr 4, 2024 · Stub1 maintains proteostasis of master transcription factors in embryonic stem cells. CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation. CHIP protects against MPP(+)/MPTP-induced damage by regulating Drp1 in two models of Parkinson's disease. personal insolvency professionals associationWebDec 21, 2024 · PubMed Abstract: Recent evidence suggests that deletion of STUB1─a pivotal negative regulator of interferon-γ sensing─may potentially clear malignant cells. … standard health insurance cayman