WebApr 2, 2024 · It is 49,000-, 16,0000-, and 13,000-fold less selective for CDK2, 9, and 12, respectively. 31 Syros Pharmaceuticals was originally developing an IV CDK inhibitor, SY-1365, but halted in 2024 to ... WebSyros is advancing a growing pipeline of investigational gene control medicines for diseases that have largely eluded other genomics-based approaches. The company’s current focus is on cancer, including immuno-oncology, and genetic diseases.
Therapeutic Strategies for HER2-Positive Breast Cancer: Exploring ...
WebBCL2 is an antiapoptotic protein commonly expressed in hematologic malignancies. Overexpression of BCL-2 is a poor prognostic factor in acute myeloid leukemia (AML). Venetoclax (ABT-199) is a highly selective BCL2 inhibitor that can induce cell death in multiple leukemia cell lines. Recently, venetoclax received an FDA breakthrough therapy … WebJan 10, 2024 · Syros also announced today that small molecule inhibitors of CDK11 and WRN are the focus of two additional oncology programs in discovery. Financial Guidance Based on its current operating plans, Syros expects that its existing cash, cash equivalents and marketable securities will be sufficient to fund its anticipated operating expenses and ... bruna biava de menezes
Syros Pharmaceuticals Announces Publication in Blood Advances ...
WebJan 27, 2024 · Its oncology business grew 4 percent year over year, from $3.78 billion in Q4 2024 to $3.93 billion in Q4 2024. The firm's oncology portfolio includes several precision … WebDec 1, 2024 · These two distinct roles have been elegantly portrayed and placed CDK7 under the spotlight of oncology. ... SY-1365 (developed by Syros Pharmaceuticals) (Table 2) inhibits CDK7 with an IC 50 of 84 nM and exhibits more potent and metabolically stable than THZ1. It demonstrates anti-cancer potency in a variety of cancer types (such as AML) at ... WebApr 14, 2024 · We used data from the Alliance for Clinical Trials in Oncology phase III trials that enrolled patients age ≥ 60 years with newly diagnosed AML between 1998 and 2002 … testplanesaabb