WebThe final step differs, with THCA synthase and CBDA synthase producing THCA or CBDA, respectively, from CBGA. Subsequent decarboxylation of THCA and CBDA via light … THCA synthase, a flavoprotein, uses a flavin adenine dinucleotide (FAD) cofactor to catalyze the oxidative cyclization of the monoterpene moiety of cannabigerolic acid (CBGA). Similar cyclization reactions occur in monoterpene biosynthesis from geranyl pyrophosphate, but are not oxidative. THCA synthase … See more Tetrahydrocannabinolic acid (THCA) synthase (full name Δ -tetrahydrocannabinolic acid synthase) is an enzyme responsible for catalyzing the formation of THCA from cannabigerolic acid (CBGA). … See more THCA synthase is expressed in the glandular trichomes of Cannabis sativa. THCA synthase may contribute to the self-defense of … See more Demand is high for pharmaceutical grade THC and other cannabinoids due to interest in their potential therapeutic use, but is stymied by legal regulations of C. sativa cultivation in many countries. Direct chemical synthesis of THC is difficult due to high costs and … See more THCA synthase is a 60 kDa (~500 amino acids) monomeric enzyme with the isoelectric point at 6.4. Post-translational N-linked glycosylation increases … See more
Cannabinoid Synthesis and the Biosynthetic Pathway
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UniProt
Web28 Nov 2024 · The gene sequences for the THCA and CBDA synthases are nearly identical, supporting the idea that they come from the same gene that was duplicated millions of … Webacid-synthase (THCA-synthase) enzyme [7,8],responsiblefortheproductionof THCfromtheCBGprecursor. Following this line, in a previous study [9] we investigated … Web1 Jun 2009 · THCA synthase is the first cannabinoid synthase to be studied and is potentially attractive target for various biotechnological applications as it produces the … talawanda school improvement plan